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ATP exposure stimulates glutathione efflux as a necessary switch for NLRP3 inflammasome activation - ScienceDirect

This reaction occurs spontaneously but in certain bacterial species, such as Paracoccus denitrificans and Rhodobacter sphaeroides , it is catalyzed by a formaldehyde-activating enzyme (Gfa, EC 4.4.1.22

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It is integrative and multisystemic